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(2016) mice were given food with different amounts of vitamin E for 6 weeks

The percentage of subjects with one deficit increased from 18 subjects (69.2%) to 19 subjects (73.1%) after 10 weeks, while the percentage of subjects with two deficits decreased from ten subjects (30.8%) to four subjects (15.4%) after 10 weeks intervention

[DOI] [PubMed] [Google Scholar] Liang Z

albicans , which triggers the activation of TANK-binding kinase 1 (TBK1)a serine/threonine kinase central to innate immune signaling cascades that regulates the production of type I interferons (IFN-I) and proinflammatory cytokines (Perry et al., 2005)

This article may help you understand why this happens and how to reduce melanin in skin to manage this condition